UGANDA MALARIA SURVEILLANCE PROJECT (UMSP)

Directors: Professor Moses Kamya, Makerere University and Dr. Grant Dorsey, UCSF

Co-Directors: Fred Wabwire-Mangen, Makerere University College of Health Sciences, School of Public Health and Ambrose Talisuna, Medicines for Malaria Venture, Sarah Staedke, LSHTM; Adoke Yeka, MU

Technical Advisors: Okui Albert Peter, Uganda National Malaria Control Program; Ebony Quinto, Uganda National Malaria Control Program; Eddii Mukoyo, MOH Health Management Information Systems

Epidemiologist/Lab and Program Coordinators: Emmanuel Arinaitwe, IDRC; Humphrey Wanzira, IDRC; Arthur Mpimbaza, MU; Asadu Sserwanga, IDRC; Ruth Kigozi, IDRC; Samuel Nsobya, MU; Moses Kiggundu, IDRC

Location: Sentinel sites throughout Uganda

Funded by: CDC President’s Malaria Initiative (PMI)

The Uganda Malaria Surveillance Project (UMSP) was established in 2001 with the purpose of creating a multi-site surveillance system for monitoring antimalarial drug efficacy and safety, malaria related morbidity and mortality and building capacity for facility based management of malaria with the goal of providing sustainable progress in malaria control. The project brings together experts from the Uganda Ministry of Health, Makerere University School of Public Health, Makerere University College of Health Sciences, London School of Hygiene and Tropical Medicine, and the University of California San Francisco. UMSP works in close partnership with other stakeholders including the Ministry of Health (MOH), the National Malaria Control Program (NMCP), CDC Uganda, the Malaria Consortium, the Infectious Disease Institute (IDI) and other key partners. UMSP has been highly successful to date, providing high quality data which has helped to guide malaria treatment policy in Uganda and provided training and capacity building for improved malaria case management. Malaria mortality and morbidity surveillance data from UMSP has been used to assess impact of control interventions and for evidence based decision making. The specific objectives for both the programmatic and research activities set out in the current cooperative agreement are as follows:

Supporting the Implementation of Malaria Prevention and Control Strategies and Relevant Ancillary Activities in the Republic of Uganda as part of the President’s Malaria Initiative (PMI)
Cooperative Agreement Number: 1U51CK000117-03

SURVEILLANCE: SENTINEL SURVEILLANCE OF MALARIA MORBIDITY AND MORTALITY

Objective 1: To strengthen and maintain an out-patient-based sentinel site surveillance system for monitoring indicators of uncomplicated malaria morbidity

Objective 2: To establish an in-patient-based sentinel site surveillance system for monitoring indicators of severe malaria morbidity and malaria mortality

Objective 3: To strengthen data management to ensure timely data analysis and the provision of reports on key malaria indicators to the Ministry of Health NMCP

MALARIA DIAGNOSTIC TRAINING: IMPROVE CAPACITY IN MALARIA CASE MANAGEMENT AND DIAGNOSTIC THROUGH TRAINING AND DEVELOP A MALARIA DIAGNOSIS QUALITY ASSURANCE SYSTEM

Objective 1: To improve diagnostic capacity for malaria and management of febrile illness in 6 districts in Uganda by training laboratory health care workers in malaria microscopy and RDTs

Objective 2: Malaria Diagnosis Quality Assurance Program

Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
Cooperative Agreement Number: U01/GH000076     

THERAPEUTIC EFFICACY TRIAL:  ROUTINE ANTIMALARIAL THERAPEUTIC EFFICACY STUDIES
Objective 1: To estimate the clinical and parasitological efficacy of two ACTs (AL and AQ+AS) for the treatment of uncomplicated P. falciparum malaria in children at three sites in Uganda

Objective 2: To evaluate the incidence of adverse events to two ACTs (AL and AQ+AS) for the treatment of uncomplicated P. falciparum malaria in children at three sites in Uganda

Objective 3: To differentiate recrudescences from new infections by the Polymerase Chain Reaction (PCR) analysis

Objective 4: To determine molecular markers in relation to reduced susceptibility to the ACTs

Objective 5: To formulate recommendations to enable the Ministry of Health make informed decisions about the possible need for updating of the current national antimalarial treatment guidelines

IMPACT EVALUATION: MALARIA CONTROL EFFORTS IMPACT EVALUATION STUDY
Objective 1: To measure the degree to which malaria control interventions have been implemented and scaled up in Uganda, as measured against targets set in the national strategic plan, as well as international goals
Objective 2: To assess malaria-related morbidity and mortality before, during, and after scale-up of malaria control interventions

Objective 3: To assess the plausible attribution of the scale-up of malaria control interventions on changes in malaria-related morbidity and all-cause and malaria-related mortality